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Siofor® (Metformin) oral tablets are used to treat high blood sugar levels caused by type 2 diabetes. They’re used in combination with diet and exercise. Siofor (Metformin) may be used as part of a combination therapy. That means you may need to take it with other meds. Metformin allows the body to make better use of the lower amount of insulin which occurs in the kind of diabetes known as type 2 diabetes.